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Nevertheless, etomoxir is proved to have some serious toxic effect 91 and thus is still in the preclinical stage
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Furthermore, an allergic reaction could lead to severe reactions such as swelling of the face, lips, tongue, and throat, trouble breathing and swallowing, severe rash, and rapid heartbeat
Upregulation of mtDNA is observed upon activation of TLR2 and TLR4, potentially contributing to the induction of local or systemic inflammation (99, 100)
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